Examining the effect of linkage disequilibrium on multipoint linkage analysis
نویسندگان
چکیده
منابع مشابه
SNPLINK: multipoint linkage analysis of densely distributed SNP data incorporating automated linkage disequilibrium removal
SUMMARY SNPLINK is a Perl script that performs full genome linkage analysis of high-density single nucleotide polymorphism (SNP) marker sets. The presence of linkage disequilibrium (LD) between closely spaced SNP markers can falsely inflate linkage statistics. SNPLINK removes LD from the marker sets in an automated fashion before carrying out linkage analysis. SNPLINK can compute both parametri...
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Linkage disequilibrium (LD) is bases of genomic selection, genomic marker imputation, marker assisted selection (MAS), quantitative trait loci (QTL) mapping, parentage testing and whole genome association studies. The Particular alleles at closed loci have a tendency to be co-inherited. In linked loci this pattern leads to association between alleles in population which is known as LD. Two metr...
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This paper describes a likelihood based fine scale linkage disequilibrium mapping method for estimating the position of a disease predisposing gene relative to a battery of typed marker loci. The method uses multilocus allele frequency data from a sample of unrelated diseased individuals and from a sample of unrelated control individuals, that is, a case and control type design. This type of da...
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Lately, many different methods of linkage, association or joint analysis for family data have been invented and refined. Common to most of those is that they require a map of markers that are in linkage equilibrium. However, at the present day, high-density single nucleotide polymorphisms (SNPs) maps are both more inexpensive to create and they have lower genotyping error. When marker data is i...
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Flowering time varies among Arabidopsis accessions. Some of the genes that contribute to this polygenic trait have been localized using quantitative trait loci (QTL) mapping, eventually leading to the identification of genetic variants that contribute to observed differences in flowering time (El-Assal et al., 2001). Despite this and other similar successes with the positional cloning of QTL, t...
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ژورنال
عنوان ژورنال: BMC Genetics
سال: 2005
ISSN: 1471-2156
DOI: 10.1186/1471-2156-6-s1-s83